treatment of transformed leukaemia
Last reviewed 01/2018
Lymphoid blast crises respond best to standard ALL therapy - prednisolone or vincristine. A second chronic phase is achieved in 40-60%.
Myeloid blast crises are managed with AML therapy. A second chronic phase is achieved in 30% of patients.
Patients in a second chronic phase should receive:
- AML or ALL maintenance therapy
- craniospinal prophylaxis:
- 6 intrathecal injections of methotrexate