management
Last reviewed 05/2023
- empirical antimicrobial therapy - consider:
- source of septicaemic organism, i.e. site
- neutropenia
- previous antibiotics
- any underlying disease
- prevailing patterns of antibiotic resistance
- whether hospital or community acquired
- oxygenation
- fluid replacement
- drainage of abscesses
- vasopressors and inotropes
New, currently experimental approaches:
- monoclonal antibodies to endotoxin
- monoclonal antibodies ot tissue mediators
empirical choice of antibiotic