clinical conditions requiring adjustment of thyroxine dose

Last reviewed 01/2018

Conditions in which an increased dose of thyroxine may be required:

• increased thyroxine clearance:
• phenytoin
• carbamazepine
• rifampicin
  
  
• reduced intestinal absorption
• ferrous sulphate
• cholestyramine
• aluminium hydroxide
  
  
• increased concentration of serum thyroxine binding globulin:
• pregnancy
• increased body mass (1)
  
  
• reduced thyroxine clearance:
• aging

Reference:

• Wood J. (1994).Thyroxine therapy. NEJM, 331 (3), 174-80.