hormonal factors
Last reviewed 01/2018
Glucogenesis is one response to a diminution of plasma glucose levels. The hormone changes in response to low plasma glucose include:
- increase in glucagon:
- increases cAMP in hepatocytes which indirectly decreases the activity of 6-phosphofructokinase and pyruvate kinase
- reduces the tendency for glycolysis to act in the opposite direction to gluconeogenesis
- decrease in insulin: change acts to increase cAMP, so acting in tandem with glucagon
- increase in glucocorticoids: permissive effect on other hormones