natural history

Last reviewed 01/2018

The histologic grade is a guide to the likely outcome of the dysplastic changes:

• CIN 1:
• 50% resolve spontaneously
• 20% progress to higher grades of dysplasia
• 30% show no change, or change too slowly to be detected

• CIN 2:
• 33% resolve spontaneously
• 33% progress
• 33% show no change

• CIN 3:
• untreated, 20-30% develop carcinoma within 10 years
• treated, 12% develop carcinoma within 30 years