regulation
Last reviewed 01/2018
Pyruvate kinase is inhibited by:
- ATP; hence, glycolysis is limited when the cell is energy-laden
- glucagon, by secondary messenger-mediated phosphorylation; hence, when plasma glucose is low the rate of glycolysis is reduced as a means of conservation for tissues in which glucose is an obligatory fuel
It is stimulated by fructose-1,6-biphosphate, so providing feedforward regulation from earlier in the glycolytic pathway.