intrinsic haemolytic anaemia

Last reviewed 09/2022

Hereditary:

• disorders of red cell membrane - for example:
• hereditary spherocytosis
• hereditary elliptocytosis
• disorders of haemoglobin synthesis - for example:
• sickle cell disease
• thalassaemia
• deficiencies of red cell enzymes - most commonly:
• glucose-6-phosphatase dehydrogenase
• pyruvate kinase

Acquired:

• membrane defect - paroxysmal nocturnal haemoglobinuria