aetiology

Last reviewed 01/2018

Examples of extravascular haemolysis include:

• sickle cell disease:
• during a crisis, hypoxia results in gelling of the HbS
• the red cell become less deformable
• phagocytosis within mononuclear cells in the spleen results in extravascular haemolysis
• hereditary spherocytosis:
• the abnormal cytoskeleton reduces the deformability of the red cells