propranolol in thyrotoxicosis

Last reviewed 01/2018

Propranolol blocks the peripheral adrenergic features of hyperthyroidism and partially inhibits the conversion of T4 to T3.

Regimen:

• initially, 40 mg tds or qds PO - this is a high initial dose and reflects the increased metabolism of propranolol in hyperthyroidism

• if there is no symptomatic relief within the first 24-48 hours, increase to 80 or 160 mg tds or qds

• continue treatment until thyroid function has returned to normal via other therapies; then withdraw gradually