criterion F

Last edited 05/2022 and last reviewed 05/2022

Either of the following:

• evidence of causative Alzheimer disease genetic mutation from family history or genetic testing
• all three of the following are present:
• clear evidence of decline in memory and learning and at least one other cognitive domain
• steadily progressive, gradual decline in cognition, without extended plateaus
• no evidence of mixed etiology (i.e. absence of other neurodegenerative disorders or cerebrovascular disease, or another neurological, mental, or systemic disease or condition likely contributing to cognitive decline.

Reference:

• (1) American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), American Psychiatric Association, Arlington, VA 2013.