diagnostic criteria for sporadic CJD
Last reviewed 01/2018
The diagnostic criteria for (classical) sporadic Creutzfeldt-Jacob disease are:
- definite diagnosis, any of the following:
- neuropathologically confirmed
- positive PrP Western blot
- presence of scrapie-associated fibrils
- probable diagnosis:
- progressive dementia
- typical EEG
- two or more of:
- myoclonus
- visual or cerebellar signs
- pyramidal/extrapyramidal signs
- akinetic mutism
- possible diagnosis:
- progressive dementia
- two of:
- myoclonus
- visual or cerebellar signs
- pyramidal/extrapyramidal signs
- akinetic mutism
- duration <2 years