side effects
Last reviewed 09/2023
The side effects of non-steroidal anti-inflammatory drugs include:
- dyspepsia and peptic ulceration
- bleeding related to antiplatelet activity
- occasionally, skin rashes
- NSAID's particularly aspirin can trigger asthma
- renal toxicity:
- most commonly acute renal failure secondary to the haemodynamic changes produced by the prostaglandin synthesis inhibition of NSAID's. This is more likely in patients who have impaired renal or hepatic function, heart failure and the elderly.
- interstitial nephritis that is not dose related
- aseptic meningitis - rare but serious
- analgesia headache
Particular care must taken in elderly patients, the renally impaired, and those with bleeding diatheses.
risk factors for gastrointestinal side-effects of NSAIDs
prevention of peptic ulceration due to NSAIDs
relative risks of side effects with different NSAIDs
COX-1 Vs COX-2 inhibitors (relative risk of GI side effects)
NSAIDs and analgesic nephropathy
non-steroidal anti-inflammatory drugs (NSAIDs) and venous thromboembolism (VTE)