mode of action

Last reviewed 01/2018

• inhibition of bacterial DNA gyrase (a topoisomerase) - this enzyme is involved in the supercoiling of DNA, and topoisomerase IV

• DNA gyrase is unique among topoisomerases in its ability to introduce negative supercoils into bacterial DNA - this supercoiling is important for initiation and propagation of DNA synthesis and transcription of mRNA from many genes

This effects results in an impairment of DNA replication and protein synthesis.