diagnosis

Last reviewed 01/2018

The criteria for diagnosis of this syndrome has been outlined by the American College of Rheumatology. The six classification criteria identified in the study were:

• asthma
• peripheral blood eosinophilia
• neuropathy
• pulmonary infiltrates
• paranasal sinus involvement
• biopsy showing vasculitis with extravascular eosinophils

The presence of four of these criteria permitted discrimination of Churg-Strauss syndrome from other vasculitidies with a sensitivity of 85% and a specificity of 99.7%.

Laboratory diagnosis is based on tissue biopsy and the antineutrophil cytoplasmic antibody (ANCA) test

• serologically, the prevalence of ANCA is anti-MPO pANCA 60% and anti-PR3 cANCA 10% and undetected in the remaining 20% (2)

This syndrome is also characterised by elevated levels of IgE.

Reference:

• (1) Mais AT et al.Arthritis Rheum 1990; 33: 1094-1100.
• (2) Davies DJ. Small vessel vasculitis. Cardiovascular Pathology 2005; 14 (6): 335-346.
• (3) Savage COS. Systemic vasculitides.Medicine International 1994;22(2): 53-7.