prostaglandin E1
Last reviewed 01/2018
Prostaglandin E1 has the following functions:
- along with PGE2, maintains ductus arteriosus patency in the newborn as a result of its general vasodilatory effect
- inhibits platelet aggregation
- gastric effects:
- increases cellular resistance to acid
- increased mucous secretion
- decreased acid secretion
- increases uterine contraction
- gastrointestinal tract: increases contraction and secretion
- negative inotropy on heart
- hypothalamic pyretic