asymptomatic raised uric acid and thiazides

Last reviewed 06/2022

• occurs in up to 30% of hypertensive patients treated with thiazide diuretics
  
  
• the presence of hyperuricaemia per se does not require withdrawal of the thiazide or treatment
  
  
• if gout develops however then it is prudent to stop thiazide treatment and initiate alternative therapy for hypertension
  
  
• if a patient has a history of gout then treatment with thiazides are best not used - if necessary concurrent treatment with allopurinol can allow continued treatment with a thiazide

Reference:

• (1) Prescriber (2001), 12 (18), 49-61.