drugs with significant first pass hepatic metabolism

Last reviewed 01/2018

The following drugs have significant first pass hepatic metabolism:

  • chlorpromazine
  • aspirin
  • oestrogens
  • enalapril
  • prazepam
  • amitriptyline
  • nortriptyline
  • imipramine
  • pentazocine
  • pethidine
  • chlormethiazole
  • isosorbide dinitrate
  • glyceryl trinitrate
  • lignocaine
  • oxprenolol
  • propranolol
  • labetolol