loss of male libido

Last reviewed 03/2023

Libido

• libido relates to a person's desire for sexual activity and sex seeking behaviour
  • levels of libido vary from person-to-person, and there is considerable individual variation, with libido changing across relationships as well in different social and environmental circumstances
  • low libido becomes a problem when it creates distress for the patient and/or their partner and difficulty across the relationship
  • unrealistic perceptions about male libido may strongly influence a man's feelings of shame and embarrassment if they experience low sex drive (1)

Assessment and management

Loss of libido is a not uncommon presenting symptom in general practice and can be affected by many factors including:

• fatigue - such as from long or irregular working hours
• stressors - from any source, but potentially related to work, finances, health or relationships
• lack of psychological wellbeing - such as depression, anxiety or low self esteem
• relationship problems - such as conflict, poor intimacy or sexual incompatibility

Systematic questioning is required to elicit symptoms in these areas, as loss of libido may need to be judged 'by the company it keeps'.

While there may be some reduction in a man's libido with ageing (as in menopausal women) this is by no means universal

Reduction in libido to discordant levels in either partner may negatively impact the relationship in terms of dissatisfaction and conflict, which could lead to the partner seeking alternative relationships

While low libido is more commonly the result of psychosocial factors, other causes must be excluded

• biological causes (eg. testosterone deficiency, diabetes, thyroid disorders and other endocrinopathies)
  • reduced libido is widely considered the most prominent symptomatic reflection of low testosterone levels in men
    • testosterone deficiency (TD) afflicts approximately 30% of men aged 40-79 years, with an increase in prevalence strongly associated with aging and common medical conditions including obesity, diabetes, and hypertension
      • decreased libido is a concern often expressed by aging patients, it is difficult to measure comprehensively, being multifactorially determined and associated with both psychosocial and organic factors
        • phenomenon of hypogonadism due to aging has also been described as testosterone deficiency syndrome, late-onset hypogonadism (LOH), and andropause
          • symptoms of this condition resemble those of 'normal' aging and include changing body composition (osteopenia, increased adiposity, decreased muscle mass), decline in energy and stamina, decreased cognitive function, decreased libido, and erectile dysfunction, systolic hypertension, carotid artery-wall thickness, increased abdominal visceral-fat mass, insulin resistance, reduced HDL concentrations, postprandial somnolence, impaired quality of life and depressive mood
      • testosterone levels in men begin to decline in the late third or early fourth decade and diminish at a constant rate thereafter
        • no universal agreement regarding the exact definition of hypogonadism. However, it is generally accepted that hypogonadism refers to the presence of persistently low circulating testosterone compared with the normal range derived from healthy young and middle-aged men. This range is approximately 10.4-34.7 nmol/L in most assays of serum total testosterone, although wide variation may exist between different commercial assays (2)
          • a suggested algorithm for assessment of possible testosterone deficiency is (3):
            • 
            • The algorithm above is based on common clinical features and an early morning (8-11am) serum testosterone
            • Illness and certain drugs can modify testosterone levels - consider as confounding factors prior to referral
            • NB: Older (especially obese) men may have borderline testosterone levels: Evidence of replacement therapy is conflicting (and possibly harmful) and probably has little role for symptoms that are not discriminant such as fatigue. Referral is unlikely to be of benefit
              
              
              • Key points:
                • investigate only once any acute illness has fully resolved
                  
                  
                • most discriminant symptoms associated with low testosterone (<11nmol/L) are: low libido, loss of early morning erections & erectile dysfunction - particularly in combination
                  
                  
                • consider endocrine referral if suggestive clinical symptoms + chronic androgen deficiency ie TWO early am (8-11am) testosterone samples <11 nmol/L at least 4 weeks apart:
                  • Refer if repeat sample <7nmol/L or those in the 7-11 range having clear hypogonadal symptoms
                  • If repeat sample 7-11 nmol/L and no clear symptoms: consider reversible causes (drug/illness)
                    
                    
                • further monitoring after several months may be appropriate
                  
                  
              • confounding, potentially reversible factors affecting testosterone. Concurrent illness, certain drugs (prescribed or otherwise) and lifestyle factors (e.g. excessive alcohol; stress; possibly weight gain/obesity) can all potentially cause reversible hypogonadism (low testosterone) or contribute to symptoms
                
                
• iatrogenic causes (eg. medications such as SSRIs, antipsychotics and beta-blockers)
• lifestyle (eg. excessive alcohol use)

Erectile dysfunction, while not necessarily a cause of low libido, may result in sexual avoidance behaviour that ultimately leads to loss of libido.

While reduction in libido is a manifestation of depression, the treatment of depression using some SSRIs may also complicate this symptom by further exacerbating low libido and/or potentially creating difficulties in reaching orgasm (anorgasmia)

Management may include information, counselling, and being mindful of the libido-reducing side effects of some medications

• if testosterone deficiency then seek expert advice re: management as described above
  • testosterone supplementation may be advised
  • there is evidence that Tradamixina (2) (150 mg of Alga Ecklonia Bicyclis, 396 mg of Tribulus Terrestris and 144 mg of D-Glucosamine and N-Acetyl-D-Glucosamine) for two months improved libido in elderly men. In this trial daily tadalafil improved erectile dysfunction but had no affect libido

Reference:

• 1) Wijesinha S, Piterman L, Kirby CN. The male reproductive system - An overview of common problems. Aust Fam Physician. 2013 May;42(5):276-8.
• 2) Iacono F et al.Sexual asthenia: Tradamixina versus Tadalafil 5 mg daily. BMC Surg. 2012;12 Suppl 1:S23.
• 3) Refhelp - Investigation of suspected hypogonadism in primary care (accessed July 10th 2013)