chloramphenicol topical treatment and agranulocytosis

Last reviewed 06/2022

• the evidence of a causal relationship between the use of topical chloramphenicol and agranulocytosis is not compelling (1,2)

Reference:

• (1) Doon M, Walsh JB (1995). Use of chloramphenicol as a topical eye medication, time to cry a halt?. BMJ, 310, 12178.
• (2) Walker S et al (1998). Lack of evidence of toxicity following topical chloramphenicol use. Eye, 12, 8759.