genetic loci

Last reviewed 01/2018

A recent genome-wide search for human type-1 susceptibility genes revealed five loci:

• IDDM1:
• chromosome 6p21
• the gene is in the major histocompatibility complex
• accounts for 42% of the familial clustering of the disease in the study

• IDDM2:
• chromosome 11p15
• this is near the insulin gene
• accounts for 10% of the familial clustering of the disease in the study

• IDDM4:
• chromosome 11q

• IDDM5:
• chromosome 6q

• a fifth locus may exist on chromosome 18