clinical effects

Last reviewed 01/2018

The most important effects of histamine are on:

• the cardiovascular system in some type I hypersensitivity reactions
• gastric secretion; increased, and H2 receptors are the target for effective antagonist drugs
• during inflammation: histamine is thought to be a key mediator involved in the early stages of acute inflammation; antihistamines have minimal effect in averting vasodilatory inflammatory responses once histamine has been depleted.