hepatocellular disease and hyperlipidaemia
Last reviewed 01/2018
- hypertriglyceridaemia is characteristic of hepatocellular disease
- due to triglyceride rich lipoproteins with density in the VLDL and LDL range (forms a broad beta-band on electrophoresis) - probably secondary to hepatic lipase deficiency and damage to remnant removal mechanisms
- HDL - consists mainly of small particles with decreased cholesteryl ester (secondary to a deficiency of lecithin:cholesterol acyl transferase (catalises the esterification of free cholesterol))