factors associated with higher risk of reccurrence or metastasis
Last reviewed 01/2018
High-risk squamous cell carcinoma are those that are high risk have a high recurrence rate after treatment and may metastasise. Various features are associated with a high-risk squamous cell carcinoma of the skin:
Histological features
- poorly differentiated, perineural invasion, depth greater than 4 mm or extending to subcutaneous tissue (Clark level 5)
Sites
- lip, ears, non-sun-exposed sites, e.g. penis, scrotum and soles of feet; in areas of previous injury, e.g. burns, irradiation and chronic ulcers
Other factors
- greater than 2 cm diameter, immunosuppression, previously treated lesion
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