risk categories for selected prognostic factors

Last reviewed 01/2018

With the identification and validation of new prognostic factors, patients can be categorised into high, intermediate and low risk for disease progression (1).

  • high risk
    • del (17p)/TP53 gene mutation
    • del (11q)
    • IgHV unmutated
    • CD38 positive
    • ZAP-70 positive
    • lymphocyte doubling time < 6 months
    • b2-microglobulin > 3.5 mg/L

  • intermediate
    • trisomy 12

  • low
    • del(13q)
    • normal cytogenetics
    • mutated IgHV (1)

Reference: