anabolic steroids and hepatic effects

Last reviewed 10/2022

Hepatic:

• various abnormal liver function tests (elevated alkaline phosphatase, aminotransferases, conjugated bilirubin, and plasma proteins) have been associated with the use of anabolic androgenic steroids (AAS)
  
  
• jaundice occasionally occurs as a result of hypersensitivity-type reaction and is usually seen after 2-5 months of therapy
  
  
• cholestasis has been reported especially with the use of 17alpha-alkylated agents
  
  
• in the majority of cases, the rise in transaminases is transient, with levels normalizing within a few weeks of discontinuation of AAS
  
  
• peliosis hepatis and hepatocellular adenomas have been seen with the use of 17alpha-alkylated AAS

Reference:

• 1) Basaria S.Androgen abuse in athletes: detection and consequences. J Clin Endocrinol Metab. 2010 Apr;95(4):1533-43.