nucleic acid amplification tests (NAATs) in investigation of vaginal discharge

Last reviewed 03/2022

Nucleic acid amplification tests

• NAATs should be used for the diagnosis of chlamydia and gonorrhoea
• combined chlamydia and gonorrhoea tests are now available
• false-positives can occur with NAATs. In areas of low disease prevalence the positive predictive value may be suboptimal (<90%) and local laboratories may advise a supplementary or confirmatory test. This should be agreed with your local laboratory.

Reference:

• 1) FSRH and BASHH Guidance (February 2012) Management of Vaginal Discharge in Non-Genitourinary Medicine Settings