U3 - RNP autoantibody

Last reviewed 01/2018

U3-RNP autoantibody

• target antigen - Fibrillarin
• occurs in 5% systemic sclerosis
• clinical association
  • isolated pulmonary arterial hypertension
  • cardiac involvement
  • myositis and poor outcome in diffuse cutaneous systemic sclerosis

Reference:

• 1) Arthritis Research Campaign (2010). Topical Reviews - Systemic sclerosis and related disorders.