classification of non Hodgkin's lymphoma (NHL)
Last reviewed 01/2018
classification
Several different classification systems have been brought forward over the past few years but none have gained universal acceptance.
- historically NHL was classified according to the International Working Formulation (IWF) as either low, intermediate or high grade based on the morphology and natural history (1).
- currently the Revised European American Lymphoma (REAL)/WHO classification is in use
REAL/ WHO classification
B-cell neoplasms
- Precursor B-cell neoplasm: precursor B-acute lymphoblastic leukemia/lymphoblastic lymphoma (LBL).
- Peripheral B-cell neoplasms
- B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma.
- B-cell prolymphocytic leukemia.
- Lymphoplasmacytic lymphoma/immunocytoma.
- Mantle cell lymphoma.
- Follicular lymphoma.
- Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type.
- Nodal marginal zone B-cell lymphoma (± monocytoid B-cells).
- Splenic marginal zone lymphoma (± villous lymphocytes).
- Hairy cell leukemia.
- Plasmacytoma/plasma cell myeloma.
- Diffuse large B-cell lymphoma.
- Burkitt lymphoma.
T-cell and putative NK-cell neoplasms
- Precursor T-cell neoplasm: precursor T-acute lymphoblastic leukemia/LBL.
- Peripheral T-cell and NK-cell neoplasms.
- T-cell chronic lymphocytic leukemia/prolymphocytic leukemia.
- T-cell granular lymphocytic leukemia.
- Mycosis fungoides/Sézary syndrome.
- Peripheral T-cell lymphoma, not otherwise characterized.
- Hepatosplenic gamma/delta T-cell lymphoma.
- Subcutaneous panniculitis-like T-cell lymphoma.
- Angioimmunoblastic T-cell lymphoma.
- Extranodal T-/NK-cell lymphoma, nasal type.
- Enteropathy-type intestinal T-cell lymphoma.
- Adult T-cell lymphoma/leukemia (human T-lymphotrophic virus [HTLV] 1+).
- Anaplastic large cell lymphoma, primary systemic type.
- Anaplastic large cell lymphoma, primary cutaneous type.
- Aggressive NK-cell leukemia.
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