WHO clinical staging of HIV/AIDS for adults and adolescents with confirmed HIV infection
Last edited 03/2018
WHO clinical staging of HIV/AIDS for adults and adolescents with confirmed HIV infection
Clinical staging is used once HIV infection has been confirmed (serological and/or virological evidence of HIV infection).
WHO clinical stage
- stage 1 - asymptomatic
- no HIV related symptoms and no signs on examination
- persistent generalised lymphadenopathy - painless enlarged lymphnodes
>1cm in two or more non-contiguous sites (excluding inguinal) in the
absence of known cause and persisting for three months or more
- stage 2 - mild symptoms
- unexplained moderate weight loss (<10% of presumed or measured body weight)
- recurrent upper respiratory tract infections (current event plus one or more in last six month period) e .g - sinisitus, tonsillitis, otitis media, pharygitis
- herpes zoster
- angular chelitis
- recurrent oral ulceration - two or more episodes in the last six months
- papular pruritic eruptions
- seborrhoeic dermatitis
- fungal nail infections e.g. - paronychia, onycholysis
- stage 3 - advanced symptoms
- unexplained moderate weight loss (<10% of presumed or measured body weight)
- unexplained chronic diarrhoea for longer than one month
- unexplained persistent fever (above 37.60 C intermittent or constant, for longer than one month)
- persistent oral candidiasis
- oral hairy leukoplakia
- pulmonary tuberculosis - current
- severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis or bacteraemia)
- acute necrotizing ulcerative stomatitis, gingivitis, periodontitis
- unexplained anaemia (<8g/dl), neutropaenia <0.5x10^9 per litre)
or chronic thrombocytopaenia (<50x10^9 per litre)
- stage 4 - severe symptoms
- HIV wasting syndrome
- pneumocystis pneumonia
- recurrent severe bacterial pneumonia
- chronic herpes simplex infection (orolabial, genital, or anorectal of more than one moths duration or visceral at any site )
- oesophageal candidiasis (or candidiasis of trachea, bronchi or lung)
- extrapulmonary tuberculosis
- Kaposi "s sarcoma
- cytomegalovirus infection (retinitis or infection of other organs)
- central nervous system toxoplasmosis
- HIV enecephalopathy
- extrapulmonary cryptococcosis including meneingitis
- disseminated non-tuberculous mycobacterial infection
- disseminated mycosis (1)
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