switching antidepressant (vortioxetine to agomelatine) in adults

Last edited 03/2023 and last reviewed 03/2023

Vortioxetine to agomelatine

Cross-taper

• cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability
  
  
• is limited experience with this switch so extra caution is required
• although interactions are not expected, agomelatine is not expected to mitigate discontinuation reactions from stopping vortioxetine

Reference:

• NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults