switching antidepressant (vortioxetine to selective serotonin reuptake inhibitors (SSRIs)) in adults

Last edited 03/2023 and last reviewed 03/2023

Vortioxetine to selective serotonin reuptake inhibitors (SSRIs)

• is limited experience with this switch so extra caution is required to avoid serotonin syndrome.

• a direct switch, i.e. stopping one antidepressant and then starting the new antidepressant the following day, is normally possible

• alternatively, stop vortioxetine; wait for a period before starting the SSRI. Clinicians should decide the duration of the washout period on a case-by-case basis.

Reference:

• NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults