switching antidepressant (vortioxetine to moclobemide) in adults

Last edited 03/2023 and last reviewed 03/2023

Vortioxetine to moclobemide

Taper, washout and switch

• gradually reduce the dose of vortioxetine and stop; wait 7 days before starting low dose moclobemide
  
  
• cross-tapering is not recommended due to the high risk of serotonin syndrome
  
  
• is limited experience with this switch so extra caution is required to avoid serotonin syndrome (1)

Reference:

• NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults