intrinsic haemolytic anaemia
Last reviewed 09/2022
Hereditary:
- disorders of red cell membrane - for example:
- hereditary spherocytosis
- hereditary elliptocytosis
- disorders of haemoglobin synthesis - for example:
- sickle cell disease
- thalassaemia
- deficiencies of red cell enzymes - most commonly:
- glucose-6-phosphatase dehydrogenase
- pyruvate kinase
Acquired:
- membrane defect - paroxysmal nocturnal haemoglobinuria
glucose-6-phosphate dehydrogenase deficiency