gastrointestinal manifestations
Last edited 08/2022 and last reviewed 08/2022
Gastrointestinal manifestations include:
- pancreatic insufficiency leading to malabsorption and failure to thrive
- gynaecomastia and other signs of chronic liver disease such as hepatosplenomegaly
- liver cirrhosis, portal hypertension, hypersplenism - which may develop because of intrahepatic bile duct obstruction caused by abnormal inspissated bile
- distal ileus obstruction syndrome - meconium ileus equivalent
- rectal prolapse (in children) - due to bulky stools
- biliary stricture
- gallstones, cholecystitis
- intussusception
- acute or chronic pancreatitis.
Reference:
- (1) NICE (October 2017) Cystic Fibrosis. Available at https://www.nice.org.uk/guidance/ng78. (Accessed on 05 June 2022)
- (2) NHS (2021) Cystic Fibrosis. Available at https://www.nhs.uk/conditions/cystic-fibrosis/. (Accessed on 05 June 2022)