treatment of reactions
Last reviewed 01/2018
Type I reactions:
- salicylates
- chloroquine
- non-steroidal anti-inflammatory agents
- corticosteroids are indicated when there is:
- severe nerve involvement, or nerve abscess
- impending paralysis
- extensive and acutely inflamed skin lesions
- physiotherapeutic measures, such as rest and splinting
Mild type II reactions:
- salicylates, chloroquine and non-steroidals are again the mainstay
Moderate/severe type II reactions:
- thalidomide (300-400mg/day) is the drug of choice
- clofazimine (200-300mg/day) may be useful but is slow-acting and may have toxic effects with prolonged use
- corticosteroids are best avoided except in patients with severe neuritis, eye complications or orchitis