second-line treatment
Last reviewed 01/2018
These include:
- oral retinoids (synthetic vitamin A derivatives)
- these have a normalising effect on epidermal growth. Oral retinoids may however
worsen Netherton's syndrome (1) and cause erosions in bullous ichthyosis erythroderma
(2)
- however isotretinoin has been used to successfully treat ichyosis vulgaris, X-linked ichthyosis, epidermolytic hyperkeratosis and lamellar ichthyosis (3)
- PUVA phototherapy and cyclosporin A have been used in Netherton's syndrome. However the results have been mixed
Reference:
- (1) Judge MR, Morgan G, Harper JI. A clinical and immunological study of Netherton's syndrome. Br J Dermatol 1994; 121:615-21.
- (2) Prescriber 2000; 11 (20):97-101.
- (3) Dermatology in Practice 2007;15(4):26-28.