mortality data
Last reviewed 01/2018
There is a dose-dependent increase in mortality in patients with coronary artery disease who take nifedipine.
Meta-analysis of 16 trials yielded the following risk ratios for total mortality in patients with coronary artery disease taking various doses of nifedipine:
- Dose per day; Risk ratio for death with 95% CI
- dose = 30-50 mg; RR = 1.06 (0.89-1.27)
- dose = 60 mg; RR = 1.18 (0.93-1.50)
- dose = 80 mg; RR = 2.83 (1.35-5.93)
The authors concluded that high doses of short-acting nifedipine should not be used in patients with coronary artery disease.
Reference:
- Furberg, CD., Psaty, BM. & Meyer, JV. (1996). Nifedipine. Dose-related increase in mortality in patient with coronary heart disease. Circulation, 92(5), 1326-31.