features
Last reviewed 01/2018
- is rarely inherited in an X-linked manner
- primary sideroblastic anaemia:
- occurs in older adults
- characterised by progressive anaemia and hepatosplenomegaly
- neutropaenia and thrombocytopaenia may develop
- leucocyte alkaline phosphatase activity is generally low
- blood film:
- dimorphic picture with normal and hypochromic cells
- in congenital cases there may be microcytosis
- in acquired cases there may be macrocytosis
- blasts will be present in cases of acute myeloid leukaemia
- in lead poisoning there will be punctate basophilia in the red cels
- bone marrow:
- ring sideroblasts in the bone marrow
- erythroid hyperplasia
- iron studies:
- raised serum ferritin
- lowered TIBC