people with a high risk of inherited pancreatic cancer

Last edited 04/2018 and last reviewed 06/2022

NICE suggest for people with inherited high risk of pancreatic cancer (1)

• ask people with pancreatic cancer if any of their first-degree relatives has had it
  
  
• surveillance should be offered for pancreatic cancer to people with:
  • hereditary pancreatitis and a PRSS1 mutation
  • BRCA1, BRCA2, PALB2 or CDKN2A (p16) mutations, and one or more first-degree relatives with pancreatic cancer
  • Peutz–Jeghers syndrome
    
    
• surveillance for pancreatic cancer should be considered for people with:
  • 2 or more first-degree relatives with pancreatic cancer, across 2 or more generations
  • Lynch syndrome (mismatch repair gene [MLH1, MSH2, MSH6 or PMS2] mutations) and any first-degree relatives with pancreatic cancer
    
    
• an MRI/MRCP or EUS should be considered for pancreatic cancer surveillance in people without hereditary pancreatitis.
• a pancreatic protocol CT scan should be considered for pancreatic cancer surveillance in people with hereditary pancreatitis and a PRSS1 mutation.
• do not offer EUS to detect pancreatic cancer in people with hereditary pancreatitis

Reference:

• NICE (February 2018). Pancreatic cancer