alternative options for women taking continuous combined oral HRT preparation containing 1mg of oestradiol

Last edited 05/2022 and last reviewed 05/2022

Alternative options for women taking continuous combined oral HRT preparation containing 1mg of oestradiol

Women taking continuous combined oral HRT preparation containing 1mg of oestradiol, can consider the following:

• Bijuve capsule 1mg oestradiol + 100 mg progesterone
  
  
• Femoston conti 1mg oestradiol + 5mg dydrogesterone
  
  
• Kliovance 1mg oestradiol + 0.5mg norethisterone acetate
  
  
• Indivina 1mg oestradiol + 2.5mg medroxyprogesterone acetate
  
  
• Indivina 1mg oestradiol + 5mg medroxyprogesterone acetate
  
  
• Or take oestrogen and progestogen separately:
  • Oral oestradiol 1mg plus either:
    • micronised progesterone: Utrogestan 100 mg orally at night daily on continuous basis
    • Or Provera 5mg orally daily on continuous basis
    • Or Norethisterone 5mg orally daily on continuous basis (1mg would be sufficient for use in a continuous combined regimen but not available in stand-alone preparations)
      • Off license use of norethisterone in progestogen only contraceptive pills (e.g. Noriday 3 x tablets of 350 micrograms a day, will provide 1.05 mg of norethisterone) may be considered as an equivalent alternative
    • Or Mirena IUS

Reference:

• British Menopause Society. HRT preparations and equivalent alternatives Information for GPs and other health professionals (Accessed 3/5/22)